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Xiaochun Yu

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Primary Appointment:
Other PIBS Depts.: Cancer Biology
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  Our lab focuses on the mechanisms of cell cycle checkpoint activation. Cell cycle checkpoints are self-defense systems of cells. When cells encounter external or internal hazards, such as X-ray, UV, DNA replication errors or mitotic stress, cell cycle checkpoints sense damages caused by these hazards, and stop cell cycle progression. It allows cells having enough time to correct these lesions before processing next round of cell cycle. Loss of cell cycle checkpoints will disrupt repair process, trigger genomic instability, and ultimately lead to tumorigenesis. Currently, by using various in vitro and in vivo approaches, we are studying the roles of several key players in the checkpoint pathways.