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Vasantha Padmanabhan

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Primary Appointment: Pediatrics-Endocrinology
Primary PIBS Dept.: Molecular and Integrative Physiology
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 DESCRIPTION OF RESEARCH
  Research focus of my laboratory is translational and mainly centers on understanding the fetal origin of pubertal and adult reproductive and metabolic disorders and the impact of native steroids and estrogenic environmental pollutants such a bisphenol-A in programming such defects. Utilizing integrative approaches ranging from cell and molecular biology as well as in vitro systems to whole animal physiology the emphasis is to understand the fundamental processes controlling reproductive cyclicity in the female, the mechanisms by which environmental / hormonal influences in early fetal life program reproductive dysfunction and metabolic dysfunction such as insulin resistance, features seen in women with Poly Cystic Ovarian Syndrome (PCOS), a major infertility disorder. Major emphasis is to identify early disruptions, underlying epigenetic mechanisms as well as develop prevention and treatment strategies that are translatable to human.