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Sue Moenter

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Primary Appointment: Molec & Integrative Physiology
Primary PIBS Dept.: Molecular and Integrative Physiology
Other PIBS Depts.: Neuroscience
PubMed Name: moenter sm
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  The overall goal of our laboratory's research is to determine the cellular and molecular mechanisms underlying episodic gonadotropin-releasing hormone (GnRH) secretion, as well as to understand the role of GnRH in presentation of various forms of hypothalamic infertility. GnRH neurons form the final common pathway for the central regulation of reproduction in all vertebrates. GnRH is released in an intermittent pattern that is critical for release of gonadotropic hormones by the pituitary gland. Further, the frequency of GnRH release changes throughout the female reproductive cycle and these changes are prerequisite for shifting the relative levels of the two gonadotropins to allow for ovarian follicular development and maturation. Persistence of high frequency GnRH release that is not frequency modulated is a hallmark of polycystic ovary syndrome (PCOS). PCOS affects approximately 8-10% of women and is a major cause of infertility and other health problems.

Despite their importance, the mechanisms underlying episodic GnRH release are not well understood. This phenomenon is often referred to as the "GnRH-pulse generator". To study this pulse-generator, we use a number of different approaches to study GnRH neurons, important upstream neurons regulating these cells (such as neurons producing kisspeptin) and glia. Current approaches include electrophysiology, calcium imaging, genetic targeting, molecular biology, and mathematical modeling. These approaches are applied to carefully designed mouse models that mimic different reproductive states.

Our research focuses on several themes. First, we want to understand the basic electrophysiological properties of GnRH neurons and how these change developmentally, throughout the reproductive cycle and as a result of reproductive state. This includes determining if rhythmicity is an intrinsic property of these cells or emerges as a network property, understanding the biophysical events underlying rhythm generation, and studying how GnRH neurons communicate to produce synchronous hormone release. Second, we are examining the physiological feedback effects of estradiol and progesterone to understand how these steroids alter the basic properties of GnRH neurons and their afferents to bring about changes in hormone release. Third, we are interested in how metabolic cues, such as obesity, and other perturbations, such as stress, alter GnRH neuronal function. Finally, we have generated models that reproduce many of the symptoms of PCOS, and are conducting experiments to understand how the function of GnRH neurons is hyperactivated in this disease state. These models are also being used to test intervention strategies for restoring fertility to these animal models, with the goal of bringing this work to clinical investigation and eventually patient care.