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Peter Mancuso

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Primary Appointment: Environmental Health Sciences
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 DESCRIPTION OF RESEARCH
  Lung infections are the third leading cause of death globally and a major cause of morbidity throughout the world regardless of socioeconomic status. In comparison with other well recognized threats to public health, lung infections account for a greater global burden of disease than cancer, heart disease, stroke, HIV/AIDS, tuberculosis, and malaria. Pneumococcal pneumonia, pneumonia caused by Streptococcus pneumoniae, is the most common cause of community-acquired pneumonia and a leading cause of death in children under the age of 5 and the elderly. In my lab, we study the innate immune response against pneumococcal pneumonia and seek to determine the molecular mechanisms by which detrimental environmental factors impair pulmonary host defense. Our goal is to identify previously unrecognized factors that disable host defense and develop novel prophylactic strategies and therapeutic agents to combat this disease.