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Doug Engel

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Primary Appointment:
Primary PIBS Dept.: Cell and Developmental Biology
Other PIBS Depts.: Bioinformatics
PubMed Name: dengel
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Lab Website



 DESCRIPTION OF RESEARCH
  Dr. Engel's research interests focus on the transcriptional regulation and genetics of embryonic development. His work on globin gene regulation provided concepts that are now broadly accepted general mechanisms (gene activation by distant enhancers via chromatin looping, sequential developmental gene activation by "competition" between promoters for enhancers, autonomous embryonic and fetal globin gene silencing through the action of orphan nuclear receptor). His discovery of the GATA family of transcription factors in 1990 led to investigation of their roles in multiple aspects of tissue-specific gene activity during embryogenesis, and his group continues to investigate the roles of GATA-2 and GATA-3 in urogenital, T lymphocyte, early hematopoietic, sympathoadrenal and endothelial development.