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Search Results for Research Area: "Molecular mechanisms of disease, genetics, genomics, and computational biology"


Faculty Search Results: Results 1 - 20 (List more/fewer results: 10 20 30 40 )
Faculty Member Brief Research Description
Peter Arvan We focus on the molecular mechanisms of protein folding and trafficking in endocrine cells, and diseases of misfolding and mistargeting.   
Alan Boyle We aim to combine computational and wet lab strategies to answer questions related to the transcriptional regulatory control of human genes using genomic tools.  
Mark Day Our research is focused on prostate and bladder epithelial adhesion and survival and the influence of the microenvironment on these processes and on tumorigenesis in these organs.  
Andrzej Dlugosz Embryonic signaling pathways in cancer initiation, progression, and maintenance  
Mara Duncan The molecular mechanisms of membrane traffic, and how it promotes cell survival during stresses including starvation.  
dan eitzman Molecular mediators of adipose tissue inflammation and effects of inflammatory adipose tissue on vascular endpoints using mouse models  
J.T. Elder Our lab uses genetics, cell biology, and immunology to better understand psoriasis. We are transitioning from a genetic to a functional approach.   
David Ferguson The Ferguson laboratory studies how mammalian cells maintain a stable genome. The proteins that accomplish this serve to prevent cancer and ensure proper functioning of the immune system. Currently, our main focus is a multi-protein complex called MRN, which is mutated in human cancer predisposition and immunodeficiency syndromes. For more information see the lab website at: http://www.pathology.med.umich.edu/fergusonlab/index.html  
Phil Gage Cell fate decisions in neural crest and mesoderm; genetic analysis of mammalian eye development; transcription factors; cell signaling pathways  
Ajit Joglekar mechanochemical signal transduction, Biophysics of macromolecular protein complexes using in vivo high-resolution fluorescence microscopy, image analysis, and engineered assays.  
Katy Keegan Mouse models of telomere dysfunction, genomic instability, and birth defects. Molecular genetics of caudal and urogenital development.   
Tom Kerppola Our laboratory investigates the regulation of transcription in mammalian cells. We use a variety of imaging approaches to visualize protein interactions and modifications in living cells and animals.  
Daniel Lawrence The Lawrence lab's primary areas of interest focus on the vascular biology of stroke and the development of atherosclerosis.  
Sofia Merajver Molecular genetics of aggressive breast cancer phenotypes and comparative studies and integrated modeling.   
Jim Morrissey Biochemistry of the human blood clotting system; structural studies of membrane lipids bound to biologically significant ligands.  
Mark Russell Using zebrafish models of cardiac development to understand the pathogenesis of human congenital cardiac defects  
Jordan Shavit We study the complex genetics of human blood clotting disorders. We are using CRISPR genome editing and next generation sequencing in zebrafish to develop large scale mutagenesis screens to identify genetic and chemical modifiers of these disorders.  
Katherine Spindler Molecular biology and pathogenesis of virus-host interactions; viral encephalitis; genetic basis of host susceptibility to mouse adenovirus infection  
Muneesh Tewari Developing minimally invasive approaches to study human disease biology with high time-resolution for early detection and monitoring of cancer   
Steve Weiss Transcriptional and post-translational regulation of the 3-dimensional cell-extracellular matrix interactions that underlie growth, development and neoplasia.  
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