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Faculty List for Program: "Cancer Biology"


Faculty Search Results: Results 1 - 20 (List more/fewer results: 10 20 30 40 )
Faculty Member Brief Research Description
Kate F. Barald Development/regeneration of sensory cells and neurons in the inner ear, studies of neurofibromatosis 1 using embryonic stem cell models   
David G. Beer Translational studies involving the molecular genetics of human lung and esophageal cancer  
Ken Cadigan My laboratory is exploring the mechanism by which Wnt signaling regulates target gene expression, using Drosophila as a model system.  
Christine Canman Cancer Pharmacology and mechanisms promoting genome stability: We are investigating how specialized DNA polymerases are regulated by the Fanconi anemia pathway and influence the therapeutic response of cells treated with ionizing radiation or DNA crosslinking agents.   
John Carethers My translational laboratory focuses on familial colorectal cancer, in particular, the consequences of defective DNA mismatch repair.  
Tom Carey In my lab we are investigating biomarkers in head and neck cancer that predict response to therapy and survival as well as identifying new targets for novel therapy. In particular we are investigating viral integration and viral gene expression profiles as risk factors in oral HPV infection and HPV-induced head and neck cancers.   
Christin Carter-Su Obesity; neuronal differentiation and function; signal transduction by receptor tyrosine kinases; JAK-Stat signaling in growth, cancer and metabolism; growth hormone signaling and cellular function; tyrosine kinase adapter proteins; diabetes; cell motility   
Maria Castro Sleeping Beauty transposase-mediated mouse brain cancer models; role of DNA repair and genomic stability in tumor progression; epigenetic studies; bioinformatics.  
Mark Chiang Our lab is focused on understanding the action of transcription factor complexes at super-enhancers that drive induction and maintenance of leukemia stem cells.  
Arul Chinnaiyan Functional genomic, proteomic and bioinformatics approaches to study cancer and understand cancer biology as well as to discover clinical biomarkers.   
Howard Crawford My laboratory studies the cell and molecular mechanisms of the origins of pancreatic cancer, largely using genetically engineered mouse models of the disease. We examine the unique properties of pancreatic epithelial cells, including their inherent plasticity of differentiation, controlled by an array of developmental factors, and how these influence and modify standard oncogene signaling. We also study how chronic inflammation of the pancreas (chronic pancreatitis) contributes to early oncogenesis and cancer progression.  
Mark Day Our research is focused on prostate and bladder epithelial adhesion and survival and the influence of the microenvironment on these processes and on tumorigenesis in these organs.  
Colin Duckett Research is focused on the role of IAP proteins in cancer, with emphasis on the potential of IAP antagonists as therapeutic agents.  
Dr. Xing Fan Study signaling pathways that regulate brain development and tumor formation to develop novel therapy targeting brain cancer stem cells.  
Eric Fearon Studies of oncogene and tumor suppressor gene defects in cancer pathogenesis, particularly gastrointestinal cancers.  
David Ferguson The Ferguson laboratory studies how mammalian cells maintain a stable genome. The proteins that accomplish this serve to prevent cancer and ensure proper functioning of the immune system. Currently, our main focus is a multi-protein complex called MRN, which is mutated in human cancer predisposition and immunodeficiency syndromes. For more information see the lab website at: http://www.pathology.med.umich.edu/fergusonlab/index.html  
Jun-Lin Guan Mechanisms of cell signaling in normal and malignant mammary stem cells, angiogenesis and vascular development, and other developmental and diseases processes using moleuclar, cell biological and mouse genetics approaches.   
Gary Hammer The long range objective of Dr. Hammerˇ¦s laboratory is to understand the cellular and molecular mechanisms by which signaling pathways and downstream transcription factors coordinate the specification of adrenocortical cells within the adrenal gland.  
Michael Imperiale We study the molecular biology of the small DNA tumor virus, BK polyomavirus.   
Venkat Keshamouni Delineating basic mechanisms and interactions in lung tumor microenvironment particularly that are mediated by the cytokine TGF-beta, and to develop therapeutic strategies to disrupt these interactions.   
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