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Patrick Hu

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Primary Appointment: Int Med-Hematology/Oncology
Primary PIBS Dept.: Cell and Developmental Biology
PubMed Name: hu pj or hu p
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 DESCRIPTION OF RESEARCH
  Insulin and insulin-like growth factor (IGF) signaling pathways play important roles in the pathogenesis of Type 2 diabetes and cancer. My lab uses C. elegans as a model for studying mechanisms of IGF signal transduction. By exploiting the experimental manipulability of C. elegans and the evolutionary conservation of signaling pathways activated by IGFs, we have identified dozens of new molecules that modulate C. elegans IGF signaling, most of which are conserved in mammals. Our work currently focuses on elucidating the roles that these molecules play in C. elegans IGF signaling pathways, with the eventual goal of examining their potential roles in the pathogenesis of Type 2 diabetes and cancer.