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Linda Samuelson

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Primary Appointment: Molec & Integrative Physiology
Primary PIBS Dept.: Molecular and Integrative Physiology
PubMed Name: samuelson lc
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  Dr. Samuelson’s research program focuses on gastrointestinal stem cells. We are interested in how basic developmental pathways and growth factors function to regulate epithelial cell proliferation and differentiation in normal physiology and disease. Our approach is to use genetically engineered mouse models and mouse and human organ culture systems to interrogate pathways regulating stem cell function. Recent studies have focused on the importance of the Notch signaling pathway to regulate stem and progenitor cells. In the intestine, we have determined that Notch plays a fundamental role in cell lineage choice between absorptive enterocytes and secretory cell types (goblet, endocrine, Paneth). These studies identified Atoh1 and Neurogenin3 as key transcriptional effectors regulating secretory cell differentiation. More recent findings demonstrate a distinct function for Notch signaling to maintain stem cells in the intestine and stomach. Our current efforts include developing human organoid systems to translate our understanding of gastrointestinal stem cells to human function and disease.