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Cory Hogaboam

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Primary Appointment: Pathology Department
Primary PIBS Dept.: Molecular and Cellular Pathology
PubMed Name: hogaboam c
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 DESCRIPTION OF RESEARCH
  Our research laboratory addresses two major themes related to chronic pulmonary disease. The first theme relates to cellular and molecular immune mechanisms that regulate the pulmonary growth and persistence of fungus in a number of experimental murine models. Specifically, we examine Aspergillus fumigatus, an ubiquitous fungal pathogen that initiates a broad spectrum of diseases ranging from lethal invasive growth to allergy and asthma. Our data to date has revealed that key immune cells such as myeloid cell progenitors, macrophages, and dendritic cells bridge the pulmonary innate and adaptive immune responses to this fungal pathogen. The second theme is more translational as we explore a grouping of clinical diseases referred to as idiopathic interstitial pneumonias (IIPs). IIPs are characterized by a lethal fibrotic response due to an exuberant fibroproliferative response by collagen producing cells in the lung. Using human tissues and isolated human cell populations, we are using large-scale genomic, proteomic and novel animal model approaches to explore the etiopathogenesis of these diseases, and, more importantly, identify novel therapeutic targets in IIPs.