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Eva Feldman

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Primary Appointment: Neurology Department
Primary PIBS Dept.: Neuroscience
Other PIBS Depts.: Bioinformatics
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  Dr. Feldman’s laboratory is interested in the role of growth factors in the pathogenesis and treatment of neurologic disorders. Their research focuses on growth factor signaling mechanisms responsible for neuronal survival and differentiation. They are particularly interested in insulin-like growth I IGF-I and its receptor (IGF-IR). IGF-I and IGF-II are potent neurotrophic factors for motor and sensory neurons and glia. Dr. Feldman’s laboratory is currently investigating the role of IGF-I:IGF-IR in protecting neurons from oxidative and toxic stressors and preventing cell death in models of diabetic neuropathy, amyotrophic lateral sclerosis (ALS) and Alzheimer's disease. Their in vitro model systems include primary motor, sensory and cortical neurons and transformed neuronal cell lines. Animal models include wild type and transgenic mice and zebrafish. The Feldman laboratory uses a wide range of techniques including transient and stable neuronal transfection, message knock down using siRNA, injection of morpholinos into zebrafish, protein analyses including western immunoblotting, dot blotting and ELISA, biochemistry and oxidative adduct measures including substrate analyses and enzyme activity and anatomical assays including immunohistochemistry, histochemistry and transmission electron microscopy. The laboratory currently includes clinician and basic scientists, postdoctoral fellows, graduate and undergraduate students and technicians all of whom are actively engaged as research teams focused on a particular aspect of neurological disease.