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Faculty Search Results: Results 1 - 10 (List more/fewer results: 10 20 30 40 )
Faculty Member Brief Research Description
Rachel Zemans   
George Zhang Experimental: yeast evolutionary genomics Computational: evolutionary genomics and systems biology   
Yan Zhang My laboratory is broadly interested in the biology, molecular mechanism and technological application of the bacterial CRISPR-Cas9 systems.  
Yang Zhang We develop methods for protein structure and function predictions, and new protocols for protein design and engineering.   
Xiang Zhou Developing statistical and computational methods for large-scale genetic and genomic studies to understand the genetic basis of phenotypic variation.  
Ji Zhu   
Anuska Andjelkovic Molecular mechanism of inflammatory remodeling of Blood brain barrier, Physiology and pathophysiology of tight junction, Blood brain barrier permeability in disease pathogenesis   
Michal Zochowski   
Weiping Zou Tumor immunopathology, biology and immunotherapy  
Erik Zuiderweg NMR methodology has now matured to the point that the systems upto 100 kDa can be studied at atomic level resolution. The proteins are in solution and carry out the conformational changes and dynamic interactions necessary for function while the heteronuclear multi-dimensional NMR experiments are running. Our group applies all aspects of these methodologies to study Hsp70 protein-folding chaperone proteins in solution. Hsp70s mediate trafficking, triaging, folding, unfolding and refolding of other proteins in vivo, from bacteria to man. The groupís high-resolution solution structure determinations of Hsp70 domains, as well as studies of atom-resolved dynamics and ligand interactions, have led to the formulation of an allosteric mechanism for these proteins. These mechanisms are being investigated in depth with large constructs (up to 60 kDa) that have become accessible for TROSY NMR studies by using 800 MHz equipment.