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David Lombard

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Primary Appointment: Pathology Department
Primary PIBS Dept.: Molecular and Cellular Pathology
PubMed Name: David B. Lombard
Department Website

  Aging is a conserved but poorly understood biological phenomenon. In lower organisms, overexpression or hyperactivity of sirtuins homologs of the yeast Sir2 deacetylase confer extended lifespan. Mammals possess seven sirtuins, called SIRT1-SIRT7. These proteins regulate diverse processes in mammals, such as metabolism, tumor suppression, and longevity. Our lab focuses on elucidating roles for SIRT5 and SIRT6, using biochemical, cellular, and mouse genetic approaches.